Endocrine Health

Health areas

Intestinal microbiome affects many endocrine diseases including diabetes mellitus and thyroid diseases

Gut dysbiosis activates Tregs, which are responsible for homeostasis of both pro-inflammatory immune response and autoimmune processes. Autoimmune thyroid diseases (including Hashimoto’s thyroiditis and Graves’ disease) are ones of the most common organ-specific autoimmune disorders of increasing prevalence, which is currently higher than 5% worldwide. Recently, alteration of gut microbiota has been observed in patients with Hashimoto’s thyroiditis in comparison with healthy controls: lower biodiversity, lower abundance of Bacteroidetes, and higher abundance of Firmicutes.

Huang Y, Li SC, Hu J, Ruan HB, Guo HM, Zhang HH, et al. Gut microbiota profiling in Han Chinese with type 1 diabetes. Diabetes Res Clin Pract (2018) 141:256–63. 10.1016/j.diabres.2018.04.032

Virili C, Stramazzo I, Centanni M. Gut microbiome and thyroid autoimmunity

Best Pract Res Clin Endocrinol Metab. 2021 May;35(3):101506

Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, et al. Alterations of the Gut Microbiota in Hashimoto’s Thyroiditis Patients. Thyroid (2018) 28(2):175–86

10.1089/thy.2017.0395

Since some probiotic strains have been reported to stabilize the levels of levothyroxine, and enable reduction of the dosage of hormone therapy in Hashimoto patients, we believe that the NORDBIOTIC strains may have beneficial effects on both intestinal dysbiosis and hormone therapy in autoimmune thyroiditis.

Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, Rochira V, Simoni M, Santi D. Front Endocrinol (Lausanne). 2017 Nov 14;8:316.

NORDBIOTIC™ strains preparation

Subjects of our research in bone health:

L. paracasei NORDBIOTIC™ LPC 100
L. plantarum NORDBIOTIC™ LP 140

Our studies